Pharmaceutical Options for Triggering of Final Oocyte Maturation in ART

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Pharmaceutical Options for Triggering of Final Oocyte Maturation in ART

Since the pioneering days of in vitro fertilization, hCG has been the gold standard to induce final follicular maturation. We herein reviewed different pharmaceutical options for triggering of final oocyte maturation in ART. The new upcoming agent seems to be GnRHa with its potential advantages over hCG trigger. GnRHa triggering elicits a surge of gonadotropins resembling the natural midcycle s...

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GnRH agonist for triggering of final oocyte maturation: time for a change of practice?

BACKGROUND GnRH agonist (GnRHa) triggering has been shown to significantly reduce the occurrence of ovarian hyperstimulation syndrome (OHSS) compared with hCG triggering; however, initially a poor reproductive outcome was reported after GnRHa triggering, due to an apparently uncorrectable luteal phase deficiency. Therefore, the challenge has been to rescue the luteal phase. Studies now report a...

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GnRH agonist for triggering final oocyte maturation: time for a critical evaluation of data.

Sir, We read with great interest the manuscript by Humaidan et al. (2011). In this review, the authors summarize the published evidence regarding the use of GnRH agonist for triggering final oocyte maturation in patients undergoing IVF. By combining the results of six recently published randomized controlled trials (RCTs), the authors suggest that when a modified luteal phase support (LPS) is e...

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GnRH agonist for triggering final oocyte maturation in the GnRH antagonist ovarian hyperstimulation protocol: a systematic review and meta-analysis.

Triggering final oocyte maturation with GnRH agonist during ovarian stimulation is feasible when inhibition of premature LH surge is performed with GnRH antagonists, and we aimed to systematically collate evidence on the clinical efficacy of GnRH agonist triggering in patients undergoing assisted reproduction in GnRH antagonist protocols. Twenty-three publications were identified by a comprehen...

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ژورنال

عنوان ژورنال: BioMed Research International

سال: 2014

ISSN: 2314-6133,2314-6141

DOI: 10.1155/2014/580171